Consequences of being born small for gestational age: More than being small

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

Being born small for gestational age (SGA), a proxy for intrauterine growth restriction (IUGR), and prenatal famine exposure are both associated with a greater risk of metabolic disease. Both associations have been hypothesized to involve epigenetic mechanisms. We investigated whether prenatal growth restriction early in pregnancy was associated with changes in DNA methylation at loci that were...

Risks for low intellectual performance related to being born small for gestational age are modified by gestational age.

OBJECTIVE We sought to study whether the association between being born small for gestational age and risk for low intellectual performance was modified by gestational age. METHODS A population-based cohort study was conducted of 352,125 boys who were born between 28 and 43 completed weeks of gestation from 1973 to 1981 in Sweden. Risk for low intellectual performance at military conscription...

Being Born Large for Gestational Age Metabolic and Epidemiological Studies

Preconception use of cART by HIV-positive pregnant women increases the risk of infants being born small for gestational age

BACKGROUND The benefits of combination anti-retroviral therapy (cART) in HIV-positive pregnant women (improved maternal health and prevention of mother to child transmission [pMTCT]) currently outweigh the adverse effects due to cART. As the variety of cART increases, however, the question arises as to which type of cART is safest for pregnant women and women of childbearing age. We studied the...

Comparative Study of Cord Lipid Profile in Small for Gestational Age and Appropriate for Gestational Age Newborn

Background: This study was conducted to compare the cord blood lipid profile in term small for gestation (SGA) and appropriate for gestational age (AGA) babies as determination of cord blood lipid profile is useful screening tool for early detection of babies at higher risk as atherosclerosis has its genesis in childhood. Methods: Study Design: Hospital based cross sectional study. Setting: ne...